My wheel is clearly out of center when looking at the chain stays but is more centered when looking at the seat stays, is this an issue with the frame or the wheel?

Had same thing on frame with qr dropouts. Temporary fixed with folded pice of beer can, permanently fixed with file.

Are your wheels true?

I’ve certainly had a true wheel, looked straight at the bottom but way off at the top. My brain can’t comprehend the geometry behind it all but I can tell you that aluminum is what it is. And steel to an extent can gently be pushed and pulled and bent back into proper shape. I’ve seen highly regarded steel bike makers doing this to a fork that was a little off on a custom jig. That’s all highly subjective stuff and hard to probably quantify and correct for, could just be one tube installed not in the right spot somewhere goofy. If you’re not getting rub or weird tire wear, and your wheel is true I would just ride it!

Silly question…but is the tire totally seated all the way around?

Check the wheel on a truing stand, if it’s true it’s either your dropout or the tire itself

OP it prolly isn’t this, but I’ve had qr wheel with broken axel. Sometimes it would lineup and sit normally, other times it would look like this. If you run out of other options consider it

I agree with others, the wheel most likely isn’t dished correctly. It will look good from the top but off on the bottom. If you can take a known good wheel and mount it

It looks like  you have sliding rear dropouts. They are probably not aligned. (Is that a Soma Wolverine BTW? Had one of those, miss that bike.)