Presented By: Allison Groseth, PhD
Speaker Biography: Allison Groseth is a virologist whose research focuses on identifying molecular determinants of pathogenesis among hemorrhagic fever-causing viruses. She performed both her undergraduate and graduate training in Canada with a BSc in Biochemistry from the University of Victoria and a PhD in Medical Microbiology from the University of Manitoba. Her PhD work was performed with the Special Pathogens Program of the Public Health Agency of Canada and focused on studying the viral determinants underlying differences in virulence between filovirus species. Her postdoctoral work at the Philipps Universität-Marburg in Germany then assessed differences in virus biology and host responses to infection associated with pathogenic/apathogenic arenavirus infection. …
Webinar: The Arenavirus-Host Cell Interface: At the Crossroads of Virus Replication, Host Cell Response and Pathogenesis
Webinar Abstract: The arenaviruses are an important group of pathogens that includes several agents of severe human disease, with symptoms that include hemorrhagic fever and neurological complications; however, closely related family members are often apathogenic. The basis for this difference remains poorly understood, although regulation of host cell responses appears to play an important role. Our work has revealed differences in the ability of highly pathogenic arenaviruses (i.e. Junín virus) and their closely-related apathogenic relatives (i.e. Tacaribe virus) to regulate the induction of apoptosis during infection, and this has led us to study both the mechanism involved and its consequences for virus biology….
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